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Ben LammWhy We're Living in a Biological Singularity With Ben Lamm | MOONSHOTS Live #297 — Key Takeaways

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Ben LammWhy We're Living in a Biological Singularity With Ben Lamm | MOONSHOTS Live #297

Peter H. Diamandis43mSep 30, 2026

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Colossal's ex-utero mammal birth is expected within 24 months, and prompt-to-phenotype bioengineering ("give me an animal that does this") is projected at under 10 years — advances driven largely by multiplex gene editing that has grown from 20 to 300+ base edits in a single delivery within one year.

Key takeaways

Colossal will birth mammals fully ex-utero (no surrogate) within 24 months

Colossal will birth mammals fully ex-utero (no surrogate) within 24 months

  • Ben Lamm: 'Within 24 months we will birth animal mammals fully ex utero from gestation through delivery'
  • Multiplex genome editing scaled from 20 to 300+ edits at 90%+ efficiency in one year
  • Now testing 1000 simultaneous edit deliveries

Engineering life from scratch is more likely than reviving everything that existed

Engineering life from scratch is more likely than reviving everything that existed

  • Ben Lamm: most organisms left no fossil record — only ~100 T-Rexes ever found though billions existed
  • Epigenetics and environment mean cloning Mozart doesn't produce Mozart's abilities
  • Programmable life design — 'engineer this thing' — is the more plausible endgame

Colossal's species selection weighs indigenous beliefs, ecosystem role, and pop culture

Colossal's species selection weighs indigenous beliefs, ecosystem role, and pop culture

  • Direwolf project consulted indigenous groups and Red Wolf Coalition, leveraging Game of Thrones
  • fame to redirect sci-fi fans toward wolf conservation
  • Explicit speciesism question — 'who gets to decide' — remains unsolved internally

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In this video

  1. 1mWoolly Mammoths, CRISPR & Colossal’s Moonshot
  2. 1mWhy Ben Lamm Entered Synthetic Biology
  3. 5mThe Business Model for AI + Biology
  4. 8mCan AI Understand a Genome?
  5. 10mDe-Extinction & Engineering Life
  6. 15mDesigning Animals & the Ethics of De-Extinction
  7. 19mAre We Entering a Biological Singularity?
  8. 20mScalable Gene Editing & DNA Synthesis
  9. 22mArtificial Wombs Within 24 Months?
  10. 23mColossal’s Next Major Breakthrough
  11. 24mMapping Genotype to Phenotype
  12. 27mMoonshots, Conservation & Ex Utero Mammals
  13. 32mCan Woolly Mammoths Help Fight Climate Change?
  14. 35mAstromech, Biodiversity & the Future of Biology

“The business model in biology is just always hard. Retrain scientists to work in Jira — that's harder than stem cell reprogramming at times.”

— Ben Lamm

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