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The Complete Guide to Fixing Your Metabolism — Key Takeaways

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The Complete Guide to Fixing Your Metabolism

Dalton (Analyze & Optimize)Feb 12, 2026

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Magnesium is the single most critical nutrient for energy metabolism, required by glycolysis, pyruvate dehydrogenase, pyruvate carboxylase, the Krebs cycle, and the urea cycle simultaneously.

Key takeaways

PDH enzyme requires B1, B3, B5, lipoic acid, Mg, and Ca to convert carbs to energy

PDH enzyme requires B1, B3, B5, lipoic acid, Mg, and Ca to convert carbs to energy

  • Pyruvate dehydrogenase (PDH) links glycolysis to the Krebs cycle; deficiency in any of its 6 cofactors stalls the entire pathway.
  • Arsenic and mercury directly inhibit PDH — heavy metal exposure can block carb metabolism at this critical junction.

Metformin and berberine inhibit the electron transport chain (Complex I)

Metformin and berberine inhibit the electron transport chain (Complex I)

  • Both are listed alongside cyanide and carbon monoxide as ETC inhibitors — they suppress the final ATP-producing step of metabolism.
  • ETC inhibition also collapses NAD+ regeneration, which stalls every upstream step including glycolysis and the Krebs cycle.

Fluoride, oxalate, and heavy metals directly block glycolysis enzymes

Fluoride, oxalate, and heavy metals directly block glycolysis enzymes

  • Fluoride, oxalate, arsenic, lead, mercury, cadmium, and excess copper all inhibit glycolytic enzymes required to convert glucose to pyruvate.
  • Mycotoxins (e.g., aflatoxin B1) also inhibit this pathway — common dietary exposures can impair carb metabolism at the first step.

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In this piece

  1. What Is Metabolism and Why It Matters
  2. Carbohydrate Breakdown: Glycolysis and Pyruvate
  3. Fat Metabolism: Beta Oxidation and Medium-Chain Fats
  4. Protein Metabolism and Ammonia Clearance
  5. Systemic Metabolic Disruptors: Genetics, Randle Cycle, and Oxidative Stress
  6. Master Regulators: Hormones, Inflammation, Muscle, and Light
  7. Metabolic Testing

“Thyroid hormone is literally THE master metabolic hormone. In terms of increasing your metabolism, nothing will do it like thyroid hormone.”

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